Scorpion Venom as Therapeutic Agent - Current Perspective

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چکیده

Scorpions and their venoms have been employed in medication since thousands of years in Asia. The scorpion venom is an extremely advanced mixture of salts, nucleotides, biogenic amines, enzymes, mucoproteins, peptides and proteins (e.g. Neurotoxins). Scorpion venoms contain peptides that block or modify ion-channel function and present some doable applications to regulate cell excitability. Specific literature regarding the results of scorpion venom elements on T-cell differentiation, autoimmunity as well as on cardiac, haematological, neoplastic and infectious diseases has been revised in this article. Several investigations highlighted their potent effects against microbes and showed their potential to modulate varied biological mechanisms that are concerned in immune, nervous, cardiovascular and neoplastic diseases. As a result of their necessary structural and purposeful diversity, it's projected that scorpion-derived peptides might be accustomed to develop new specific medicine. This review is focused on the therapeutic potential of scorpion venoms and toxins and also the doable mechanisms for their anticancer, anti-inflammatory, antimicrobial activities and for the treatment of autoimmune, cardiac, hematological, infectious, osteoporosis, homeostasis and neurological diseases.

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تاریخ انتشار 2016